Absorption Enhancer and Polymer (Vitamin E TPGS and PVP K29) by Solid Dispersion Improve Dissolution and Bioavailability of Eprosartan Mesylate
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چکیده
منابع مشابه
Preparation and evaluation of carvacrol pellets based on PVP solid-dispersion by extrusion-spheronization technique
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The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Tadalafil a BCS class II drug is an impotence agent. It is indicated for the treatment of erectile dysfunction and is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5).However, insolubility and poor dissolut...
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The aim of this study was to develop celecoxib-polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. The effect of different surfactants such as gelucire 44/14, poloxamer 188, poloxamer 407, Ryoto sugar ester L1695, and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on nanoparticle formation and dissolu...
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Oral drug delivery is considered as the most preferable route for chronic treatment of various diseases, due to its greater stability, flexibility in formulation, dosage accuracy, low cost of manufacturing and packaging and patient friendly administration [1]. But most of the drugs belong to poorly water soluble (BCS Class II) category and suffering from poor dissolution and it is worst if give...
متن کاملexistence and approximate $l^{p}$ and continuous solution of nonlinear integral equations of the hammerstein and volterra types
بسیاری از پدیده ها در جهان ما اساساً غیرخطی هستند، و توسط معادلات غیرخطی بیان شده اند. از آنجا که ظهور کامپیوترهای رقمی با عملکرد بالا، حل مسایل خطی را آسان تر می کند. با این حال، به طور کلی به دست آوردن جوابهای دقیق از مسایل غیرخطی دشوار است. روش عددی، به طور کلی محاسبه پیچیده مسایل غیرخطی را اداره می کند. با این حال، دادن نقاط به یک منحنی و به دست آوردن منحنی کامل که اغلب پرهزینه و ...
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ژورنال
عنوان ژورنال: Bulletin of the Korean Chemical Society
سال: 2011
ISSN: 0253-2964
DOI: 10.5012/bkcs.2011.32.5.1587